延边大学学报(自然科学版)

为了探讨胫骨高位截骨术(HTO)联合富血小板血浆(PRP)治疗膝关节内侧骨性关节炎(MKOA)的临床疗效及软骨再生机制,选取150例MKOA患者进行了研究.研究分为HTO组、PRP组和联合组(HTO+PRP组),每组50例.结果显示:在术后3个月、6个月,联合组的VAS评分显著低于HTO组和PRP组(P<0.05);在术后12个月,联合组的Lysholm评分、IKDC评分、软骨再生Ⅱ级及以上占比、血清中的IL-6和TNF-α降幅均显著优于HTO组和PRP组(P<0.05).影像学显示,HTO组和联合组的FTA、MPTA矫正结果无差异(P>0.05).上述表明,HTO+PRP在治疗MKOA过程中可协同发挥力学矫正与生物修复作用,并可促进软骨再生,因此该联合治疗方案可为保膝治疗提供良好参考.

To investigate the clinical efficacy and cartilage regeneration mechanism of high tibial osteotomy(HTO) combined with platelet rich plasma(PRP) in the treatment of medial knee osteoarthritis(MKOA), a study was conducted on 150 patients with MKOA.The patients were divided into three groups: the HTO group, the PRP group, and the combination group(HTO+PRP), with 50 patients in each group.The results showed that at the 3 rd and 6 th months postoperatively, the VAS scores of the combination group were significantly lower than those of the HTO and PRP groups(P<0.05).At the 12 th month postoperatively, the Lysholm score, IKDC score, proportion of cartilage regeneration grade II and above, reduction in serum IL-6 levels, and reduction in TNF-α levels in the combination group were significantly better than those in the HTO and PRP groups(P <0.05).Imaging results indicated no significant difference in the correction of FTA and MPTA between the HTO group and the combination group(P> 0.05).These findings demonstrate that the combination of HTO and PRP synergistically provides mechanical correction and biological repair in the treatment of MKOA, promoting cartilage regeneration.Therefore, this combined treatment approach offers a valuable reference for knee-preserving therapy.